Melanonychia Secondary to Long-Term Treatment with Hydroxycarbamide: An Essential Thrombocytosis Case

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Melanonychia Secondary to Long-Term Treatment with Hydroxycarbamide: An Essential Thrombocytosis Case

Hydroxycarbamide is used in the treatment of essential thrombocytosis and other myeloproliferative disorders. We report the case of a 63-year-old woman with essential thrombocytosis who had melanonychia after the long-term use of the hydroxycarbamide with a dose of 1000 mg/day. Two years after the initiation of the hydroxycarbamide, our patient had pain on her toes and melanonychia on her nails...

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Melanonychia commonly appears as a longitudinal band, starting from the matrix and extending to the tip of the nail plate. Less often it presents a transverse band or may inolve whole nail plate. Cutaneous side effects of hydroxyurea are described in 13% of patients including increased pigmentation, hyperkeratosis, skin atrophy, xerosis, lichenoid eruptions, palmar and plantar keratoderma, cuta...

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ژورنال

عنوان ژورنال: Case Reports in Hematology

سال: 2015

ISSN: 2090-6560,2090-6579

DOI: 10.1155/2015/653178